Effect Of Chitosan Oligosaccharide-Conjugated Selenium On Improving Immune Function And Blocking Gastric Cancer Growth

Selenium (Se) is a potential chemopreventive or chemotherapeutic agent against malignant tumor. Selenium-oligosaccharides are important selenium source of dietary supplementation. Due to the insufficient natural production, it is therefore urgent to develop selenium-oligosaccharides by artificial synthesis. Chitosan, the N-deacetylated derivative of chitin, has been gived widely in biomedical field, owing to its nontoxicity, hydrophilicity, biocompatibility, and biodegradation. While chitosan is water insoluble at neutral pH, limiting its application in physiological conditions. Chitosan oligosaccharide (COS), the hydrolysate of chitosan, is readily soluble in water because of the shorter chain durations of the oligomers and the free amino groups in the D-glucosamine wholes.

This study was aimed at grooming COS-conjugated selenium (COS-Se) and examining the toxicity and ability on meliorating immune function and embarrassing gastric cancer growth.  vitamin d3 deficiency  demonstrated that COS-Se exposed directly co-mitogenic and mitogenic actions on mouse splenocytes proliferation in vitro COS-Se treatment could effectively elevate phagocytosis and increase the secretion of anti-inflammatory cytokine in mouse peritoneal macrophages. Further in vivo experimentations demonstrated that COS-Se displayed immuno-raising effects through furthering the phagocytic index, spleen index and thymus index with no obvious toxicity to Kunming mice COS-Se inhibited proliferation and metastasis of human gastric cancer cadres, with non-toxic essences on the normal fibroblast cubicles in vitro. COS-Se supplementation could significantly repress the growth of gastric adenocarcinoma through shrinking stratums of CD34, vascular endothelial growth factor and matrix metalloproteinase-9 of nude mice. In conclusion, COS-Se was non-toxic and showed great potential as a functional food ingredient in cancer prevention.Chitosan and procyanidin composite pictures with high antioxidant activity and pH responsivity for cheese packaging.Chitosan-procyanidin composite movies (CS-PC cinemas) with different mass proportions were maked by solution couching method.

Their structural, thermal, physical, and antioxidant attributes, antibacterial activity and pH responsivity were decided. Compared with CS-control film, CS-PC flicks presented lower solubility and higher tensile strength. The antimicrobial properties against Escherichia coli and Aspergillus niger were improved by 20% and 30%, respectively. CS-PC movies designated good antioxidant activity through their DPPH and ABTS(+) cleaning rates, which were 2 metres higher than CS-control film. pH responsivity was represented by the outstanding varietys in color, which were visible to the naked eye. Food packaging film with high antioxidant activity, bacteriostatic dimensions and pH responsivity was educated by CS and PC. likened with the initial attributes of cheese, the characteristics of cheese boxed with CS-PC celluloids were obviously better than those of the control radicals.

Photocatalytic degradation of crystal violet dye under sunlight by chitosan-encapsulated ternary metal selenide microspheres.Organic dyes that are extensively released in wastewater from various industries remain the priority concern in the modern world a novel catalyst, bismuth-iron selenide, was prepared through the solvothermal process for photocatalytic degradation of a carcinogenic crystal violet dye. The catalyst was supported with chitosan to form iron-bismuth selenide-chitosan microspheres (BISe-CM). The synthesized catalyst was composed of iron, bismuth, and selenium in a definite proportion finded on EDX analysis. FTIR analysis substantiated the synthesis of BISe-CM from characteristic bands of metal selenium bond as well as the typical stripes of chitosan.  d3 vitamin food  illustrated the average diameter of the barren catalyst to be 54 nm, while the average size of the microspheres was 982 um. The BISe-CM has the surface of a pore with an average size of 0 um.

XRD analysis revealed that the synthesized catalyst was writed of Fe(3)Se(4) and Bi(2)Se(3). The prepared catalyst established better degradation efficiency for crystal violet dye at optimized considerations under solar irradiation.